What is PMDD? Premenstrual Dysphoric Disorder (PMDD) affects millions of people worldwide. It refers to a collection of cyclical symptoms that occur in the luteal phase of the menstrual cycle, about 1-2 weeks before menstruation, and resolve once bleeding begins. PMDD involves a mix of physical and emotional symptoms that occur before menstruation. Common symptoms include: Physical : Bloating, breast tenderness, headaches, fatigue, joint and muscle pain, food cravings, abdomi